N.I.H. study, Bethesda, Maryland, USA
Jay N. Giedd, MD
Principal Investigator

The Child Psychiatry Branch of the National Institute of Mental Health is conducting a study of the effects of sex chromosomes on brain development. This study hopes to determine whether brain-imaging studies of children with sex chromosome variations will help uncover core biological features of these chromosomal conditions.

Male and female volunteers aged 5-25 with a sex chromosome variation (XXY, XYY, XXYY, XXXY, XXXXY, XXX) are needed to participate in this study. Participation involves coming to the National Institutes of Health (NIH) in Bethesda, Maryland (just outside of Washington D.C.) for a one-day visit, which will include:

an interview
a brief physical exam
cognitive testing
a blood draw for genotyping
and a brain magnetic resonance imaging (MRI) scan (the MRI scan provides detailed images of the brain without the use of radiation)
We also ask that the child and parents return 2 years after the first visit for a follow-up MRI.

For participants who live outside of the Washington D.C. area, transportation and lodging for a 2-night stay will be provided for the child and two parents. In addition, each participant will receive a summary of test results and a souvenir photo of his brain.

For more information about the NIH Klinefelter Syndrome Study, Sex Chromosome Variations Study, and Triple X Syndrome Study, contact:

Jonathan Blumenthal, M.A., Project Coordinator

Phone: 301-435-4516

Email: Jonathan Blumenthal
NIMH Child Psychiatry Branch
Building 10, Room 4C110
Bethesda, MD 20892-1367
Fax (301) 480-8898
Click here to read more

[English section] [Studies]